Dosing and Administration HCP ALL

Xatmep Offers Convenient Dosing and Administration

Ready-to-use methotrexate oral solution
  • Xatmep is convenient to dispense.
  • Xatmep requires no time to prepare versus cutting or crushing methotrexate tablets or compounding tablets into a liquid formulation.

FDA-Approved Dosing and Administration — For Oral Use Only

For Acute Lymphoblastic Leukemia (ALL)

Recommended starting dose 20 mg/m2 given one time weekly. Instruct patients/caregivers that the recommended dose should be taken weekly, as directed. Mistaken daily use has resulted in fatal toxicity.
Accurate dosing Advise patients/caregivers to ask their pharmacist for an accurate (mL) dosing device. Tell patients/caregivers that a household teaspoon is not an accurate dosing device.
Periodic monitoring After initiating Xatmep, continuation of appropriate dosing requires periodic monitoring of absolute neutrophil count (ANC) and platelet count to assure sufficient drug exposure (i.e., to maintain ANC at a desirable level) and to adjust for excessive hematological toxicity.
Storage Store refrigerated (2°C – 8°C/36°F – 46°F) in a tightly closed container. Patients may store Xatmep either refrigerated (2°C – 8°C/36°F – 46°F) or at room temperature (20°C – 25°C/68°F – 77°F); excursions permitted to 15°C – 30°C/59°F– 86°F. If stored at room temperature, discard after 60 days. Avoid freezing and excessive heat.
If oral dosing is inappropriate Use another formulation of methotrexate.
Oral solution ensures consistent potency and stability
  • Same potency from first to last dose.
  • Same formulation at hospital and home.
  • Store refrigerated (2°C – 8°C/36°F – 46°F) in a tightly closed container. Patients may store Xatmep either refrigerated (2°C – 8°C/36°F – 46°F) or at room temperature (20°C – 25°C/68°F – 77°F); excursions permitted to 15°C – 30°C/59° – 86°F. If stored at room temperature, discard after 60 days. Avoid freezing and excessive heat.
  • No shaking necessary prior to administration.

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