Patients ALL

The first and only FDA-approved methotrexate oral solution for the treatment of pediatric patients with ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) as part of a multi-phase, combination chemotherapy maintenance regimen.



It’s the first and only FDA-approved oral liquid form of a medicine called methotrexate. Because it’s FDA-approved, you can be sure it’s a high-quality product.

Before Xatmep, there was no FDA-approved, ready-to-use oral liquid formulation of methotrexate for use by pediatric patients requiring body surface area (BSA) dosing (mg/m2) or who have difficulty swallowing, cannot consume tablets, or would like an alternative to methotrexate injections.

Xatmep Dosing Information—For Oral Use Only—One Time Weekly

Your doctor will tell you how much Xatmep that you or the patient should take. Do not change the dose of Xatmep unless your doctor tells you to do so.

  • Xatmep should be taken at the time and frequency specified by your doctor.
  • Always carefully measure the prescribed dose of Xatmep before you or the patient takes it. You or the patient can ask the pharmacist for an accurate (mL) dosing device. A household teaspoon is not an accurate dosing device.
  • The recommended starting dose is 20 mg/m2 given one time weekly. Mistaken daily use has resulted in fatal toxicity.
  • Make sure that you or the patient swallows the entire dose of Xatmep.
  • Store refrigerated (2°C – 8°C/36°F – 46°F) in a tightly closed container. Patients may store Xatmep either refrigerated (2°C – 8°C/36°F – 46°F) or at room temperature (20°C – 25°C/68°F – 77°F); excursions permitted to 15°C – 30°C/59° – 86°F. If stored at room temperature, discard after 60 days. Avoid freezing and excessive heat.
  • If you have questions about Xatmep, ask your doctor or your pharmacist.

Missed a dose of Xatmep?
If you or the patient misses a dose of Xatmep, contact your doctor. Do not use more medicine or use it more frequently than your doctor has prescribed.

Patients May Pay No More Than $30 For Xatmep*

If you have commercial insurance, you may pay no more than $30 for your prescription with the Xatmep co-pay programs. The automatic savings is instantly applied to your co-pay at the pharmacy. It’s completely paperless, so there are no cards, coupons, or forms.

For eVoucherRx™ questions, please call: 800‐388‐2316 Relay Pharmacy Help Desk/Customer Support. Or you can Search Now for a list of participating pharmacies.

For Voucher On Demand™ questions, please call: 866-379-6389 eRx Network, LLC. Help Desk/Customer Support.

*See Xatmep co-pay programs eligibility restrictions, terms, and conditions.


How do I use the Xatmep Voucher programs?
It’s easy. You don’t need any cards or coupons. Take your Xatmep prescription to one of many participating pharmacies nationwide. When you pick up your prescription, you’ll get an automatic co-pay reduction that ensures you’ll pay no more than $30 for Xatmep if your co-pay is $230 or less.

How much money will I save?
Qualifying patients will pay no more than $30 for a Xatmep prescription. Savings depends on the amount of your co‐pay above $30.

*Eligibility Restrictions, Terms, and Conditions

By participating in this savings program, participants understand and agree that the information provided, as well as non-personally identifiable information obtained from the pharmacy, will be shared with the manufacturer and with any companies working with the manufacturer. Participants also affirm that they will not submit, and have not had submitted on their behalf, a claim for reimbursement or coverage for items purchased with this card under Medicaid, Medicare, TRICARE, or any other federal or state government healthcare program, or where prohibited by state law.

  • Offer applies to out‐of‐pocket expenses (co‐pay) greater than $30. Out‐of‐pocket expenses greater than $30 will be covered up to $230 per prescription. If your total out‐of‐pocket cost exceeds $230, you will be responsible for a $30 co‐pay plus any additional amount over $230. If your co‐pay is already $30 or less, this offer does not apply.
  • Offer applies only to Xatmep patients and associated refills.
  • This offer is not valid for prescriptions paid in part or in full by any federally or state‐funded program, including but not limited to Medicaid, Medicare, Department of Veterans Affairs, Department of Defense, or TRICARE, and where prohibited by law.
  • For questions about eVoucherRx™, please call: 800‐388‐2316 Relay Pharmacy Help Desk/Customer Support.
  • For questions about Voucher On Demand™, please call: 866‐379‐6389 eRx Network, LLC. Help Desk/Customer Support.
  • This savings program cannot be combined with any other coupon, certificate, voucher, or similar offer.
  • Offer good only in the USA at participating retail pharmacies and cannot be redeemed at government‐subsidized clinics. Void where taxed, restricted, or prohibited by law.
  • Offer not extended to clubs, groups, or organizations.
  • Participation in this program must comply with all applicable laws and contractual or other obligations as a pharmacy provider.
  • This is not an insurance program.
  • Participating patients and pharmacists understand and agree to comply with the Terms and Conditions of this offer as set forth herein.
  • Any step‐edits or prior authorizations required by the insurance plan still apply.
  • Silvergate Pharmaceuticals, Inc. reserves the right to modify or cancel this program at any time.
  • eVoucherRx™ and Voucher On Demand™ are not extended on prescriptions for patients:
    • who are cash‐paying customers.
    • using institution-based pharmacies to fill their prescriptions, or who are recipients of federal or state government health care.
    • who are filling their prescriptions at nonparticipating pharmacies.
eVoucherRx™ is a trademark of RelayHealth. Voucher On Demand™ is a trademark of eRx Network, LLC.